Image MIME Reference
DNG
Adobe Digital Negative
image/x-adobe-dng
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of Adobe Digital Negative and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | DNG | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | Yes | ✕ No |
| Animation Support | ✕ No | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
Adobe Digital Negative
image/x-adobe-dng
Extension
.dng
Container
TIFF/EP
Compression
Lossless JPEG / Deflate / Lossy JPEG (DNG 1.4+)
Algorithm
Lossless JPEG (Standard)Lossy JPEG (Compression option)Uncompressed
Color Depth
12-bit, 14-bit, 16-bit, 32-bit (Floating Point HDR)
Developed by
Adobe Systems
Released
2004
Magic Bytes
49 49 2A 00 or 4D 4D 00 2A
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | DNG | PCO-B16 |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
DNG
DNG Strengths
- Openly documented specification guarantees long-term archival accessibility, freeing photographers from proprietary manufacturer lock-in
- Lossless compression algorithms often result in files 15-20% smaller than uncompressed proprietary raw formats
- Natively supported by modern smartphone operating systems (iOS and Android) for high-end mobile photography
Limitations
- Conversion from proprietary raw to DNG takes processing time and can strip specific, proprietary manufacturer metadata (like active D-Lighting or in-camera lens corrections)
- File sizes are massive compared to standard JPEGs or HEIC files
- Cannot be rendered natively in web browsers without server-side processing or WebAssembly decoders
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
DNG
Use DNG when…
- Digital Photography Archival
- Mobile Raw Capture (iOS ProRAW / Android Camera2 API)
- Cross-Platform Raw Editing Workflows
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry