Image MIME Reference
AVIF
AV1 Image File Format
image/avif
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of AV1 Image File Format and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
AVIF wins on browser support
Feature Support
| Feature | AVIF | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | Yes | ✕ No |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
AV1 Image File Format
image/avif
Extension
.avif
Container
HEIF / ISOBMFF
Compression
AV1 Lossy / AV1 Lossless
Algorithm
AV1
Color Depth
8-bit, 10-bit, 12-bit
Developed by
Alliance for Open Media (AOMedia)
Released
2019
Magic Bytes
XX XX XX XX 66 74 79 70 61 76 69 66
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | AVIF | PCO-B16 |
|---|---|---|
Chrome
|
✓ 85+
|
✕ |
Firefox
|
✓ 93+
|
✕ |
Safari
|
✓ 16+
|
✕ |
Edge
|
✓ 121+
|
✕ |
IE (Legacy)
|
✕ | ✕ |
AVIF
AVIF Strengths
- Best-in-class compression — typically 20–50% smaller than WebP at equivalent quality
- Native HDR and wide color gamut (BT.2020) support
- Supports 8, 10, and 12-bit color depth
Limitations
- Encoding is highly CPU-intensive — significantly slower than JPEG or WebP
- Requires Edge 121+ (not supported in earlier Edge versions)
- Limited support in native desktop image viewers
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
AVIF
Use AVIF when…
- Next-Gen Websites
- HDR Photography
- High-Quality Web Images
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry