Image MIME Reference
PCO-B16
PCO B16 Image
image/vnd.pco.b16
VS
Extended Image File Format
image/vnd.xiff
XIFF
A complete technical comparison of PCO B16 Image and Extended Image File Format — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | PCO-B16 | XIFF |
|---|---|---|
| Transparency (Alpha) | ✕ No | ✕ No |
| Animation Support | ✕ No | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | ✕ No | ✕ No |
| EXIF Metadata | ✕ No | ✕ No |
| ICC Color Profile | ✕ No | ✕ No |
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Extended Image File Format
image/vnd.xiff
Extension
.xif
Container
TIFF-based Proprietary Container
Compression
CCITT Group 3 / Group 4 / LZW / Uncompressed
Algorithm
CCITT Group 4LZWNone
Color Depth
1-bit (Monochrome), 8-bit (Grayscale), 24-bit (RGB)
Developed by
Keyfile Corporation
Released
1994
Magic Bytes
49 49 2A 00 or 4D 4D 00 2A
Browser Support Comparison
| Browser | PCO-B16 | XIFF |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
XIFF
XIFF Strengths
- Pioneered early enterprise document workflow integration by binding administrative routing data directly to the document image file
- Leveraged efficient fax compression standards to keep storage requirements low on 1990s server infrastructure
Limitations
- Completely proprietary and obsolete; Keyfile Corporation's software ecosystem no longer exists
- Causes widespread MIME type identification conflicts due to sharing the exact same binary header signature as standard TIFF files
- Zero support in modern operating systems or web browsers
When to choose which format
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry
XIFF
Use XIFF when…
- Keyfile Enterprise Document Management
- Legacy Corporate Workflow Archival
- Scanned Multi-page Document Routing