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Image MIME Reference
PCO-B16

PCO B16 Image

image/vnd.pco.b16
VS

GIMP Image Format

image/x-xcf
XCF

A complete technical comparison of PCO B16 Image and GIMP Image Format — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature PCO-B16 XCF
Transparency (Alpha) ✕ No Yes
Animation Support ✕ No Yes
Progressive Loading ✕ No ✕ No
HDR Support ✕ No Yes
EXIF Metadata ✕ No Yes
ICC Color Profile ✕ No Yes
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container PCO B16 Binary Container
Compression Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth 16-bit (Monochrome or Bayer Raw Color)
Developed by PCO AG (Excelitas PCO GmbH)
Released Early 2000s
Magic Bytes
50 43 4F 2D
Full PCO-B16 reference →
GIMP Image Format
image/x-xcf
Extension
.xcf
Container GIMP Hierarchical Chunk Container
Compression None / RLE (Run-Length Encoding) / Zlib / Deflate (In newer GIMP versions)
Algorithm
NoneRLEZlib
Color Depth 8-bit per channel, 16-bit per channel, 32-bit floating point
Developed by Spencer Kimball, Peter Mattis, and the GIMP Development Team
Released 1995
Magic Bytes
67 69 6D 70 20 78 63 66
Full XCF reference →

Browser Support Comparison

Browser PCO-B16 XCF
Chrome Chrome
Firefox Firefox
Safari Safari
Edge Edge
IE IE (Legacy)
PCO-B16

PCO-B16 Strengths

  • Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
  • The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
  • Generates massive file sizes due to the complete lack of image compression [1.3.1]
  • Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
  • Strictly tied to the hardware and software ecosystems of a single camera manufacturer
XCF

XCF Strengths

  • Preserves all non-destructive editing elements, layer hierarchies, masks, and alpha channels across GIMP sessions
  • Open and thoroughly documented specification within the open-source community, allowing third-party tools like Krita and ImageMagick to read project files
  • Reliable magic byte header prevents misidentification
Limitations
  • Massive file sizes because raw, unflattened layer bitmaps and masks are stored directly within the project archive
  • Completely proprietary to the GIMP ecosystem for deep editing; cannot be natively rendered or parsed by web browsers
  • Third-party software supporting XCF may occasionally struggle to render complex text layer adjustments or advanced layer blend modes identically to GIMP

When to choose which format

PCO-B16
Use PCO-B16 when…
  • Microscopy and Life Sciences
  • High-Speed Camera Recording
  • Machine Vision and Industrial Inspection
  • Scientific Photometry
XCF
Use XCF when…
  • GIMP Native Project Archival
  • Layered Photo Editing and Graphic Design
  • Intermediary Asset Preparation for Export
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