Image MIME Reference
PCO-B16
PCO B16 Image
image/vnd.pco.b16
VS
WebP Image
image/webp
WebP
A complete technical comparison of PCO B16 Image and WebP Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
WebP wins on browser support
Feature Support
| Feature | PCO-B16 | WebP |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | ✕ No | Yes |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | ✕ No | ✕ No |
| EXIF Metadata | ✕ No | Yes |
| ICC Color Profile | ✕ No | Yes |
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
WebP Image
image/webp
Extension
.webp
Container
RIFF
Compression
Lossy / Lossless
Algorithm
VP8VP8L
Color Depth
8-bit
Developed by
Google
Released
2010
Magic Bytes
52 49 46 46 XX XX XX XX 57 45 42 50
Browser Support Comparison
| Browser | PCO-B16 | WebP |
|---|---|---|
Chrome
|
✕ |
✓ 32+
|
Firefox
|
✕ |
✓ 65+
|
Safari
|
✕ |
✓ 14+
|
Edge
|
✕ |
✓ 18+
|
IE (Legacy)
|
✕ | ✕ |
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
WebP
WebP Strengths
- Superior lossy compression — 25–35% smaller than JPEG at equivalent quality
- Supports both animation and full alpha transparency
- Lossless mode available with smaller file sizes than PNG
Limitations
- Slower encoding than JPEG, especially for lossless
- Not supported in Internet Explorer or very old browsers
When to choose which format
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry
WebP
Use WebP when…
- Websites
- Ecommerce
- Mobile Apps
- CMS Images