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Image MIME Reference
PCO-B16

PCO B16 Image

image/vnd.pco.b16
VS

Tagged Image File Format (Legacy MIME)

image/x-tiff
TIFF

A complete technical comparison of PCO B16 Image and Tagged Image File Format (Legacy MIME) — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature PCO-B16 TIFF
Transparency (Alpha) ✕ No Yes
Animation Support ✕ No ✕ No
Progressive Loading ✕ No ✕ No
HDR Support ✕ No Yes
EXIF Metadata ✕ No Yes
ICC Color Profile ✕ No Yes
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container PCO B16 Binary Container
Compression Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth 16-bit (Monochrome or Bayer Raw Color)
Developed by PCO AG (Excelitas PCO GmbH)
Released Early 2000s
Magic Bytes
50 43 4F 2D
Full PCO-B16 reference →
Tagged Image File Format (Legacy MIME)
image/x-tiff
Extension
.tiff.tif
Container IFD (Image File Directory) Tag Structure
Compression Uncompressed / LZW (Lossless) / ZIP / Deflate (Lossless) / PackBits (Lossless RLE) / JPEG (Lossy) / CCITT Group 3/4 (Fax/Document)
Algorithm
NoneLZWDeflatePackBitsJPEGCCITT
Color Depth 1-bit (Monochrome), 8-bit (Grayscale or Indexed), 16-bit (Per Channel), 32-bit (Float Per Channel)
Developed by Aldus Corporation (Later acquired by Adobe Systems)
Released 1986
Magic Bytes
49 49 2A 00 (Little-endian) or 4D 4D 00 2A (Big-endian)
Full TIFF reference →

Browser Support Comparison

Browser PCO-B16 TIFF
Chrome Chrome
✕ ✕
Firefox Firefox
✕ ✕
Safari Safari
✕ ✕
Edge Edge
✕ ✕
IE IE (Legacy)
✕ ✕
PCO-B16

PCO-B16 Strengths

  • Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
  • The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
  • Generates massive file sizes due to the complete lack of image compression [1.3.1]
  • Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
  • Strictly tied to the hardware and software ecosystems of a single camera manufacturer
TIFF

TIFF Strengths

  • Universally accepted as the gold standard for high-fidelity archival and professional print workflows
  • Highly adaptable structure supports multiple pages (documents), layers, vast bit depths, and diverse compression algorithms within a single file
  • Unmatched support for rich metadata including EXIF, IPTC, XMP, and custom ICC color profiles
Limitations
  • Produces exceptionally large file sizes compared to modern web formats
  • The 'x-tiff' legacy MIME string forces developers to write extra validation logic to prevent strict security filters from rejecting valid uploads
  • The format's immense complexity means that many lightweight parsers only implement a subset of the specification, sometimes failing to read obscure compressions (like CCITT or old JPEG-in-TIFF)

When to choose which format

PCO-B16
Use PCO-B16 when…
  • Microscopy and Life Sciences
  • High-Speed Camera Recording
  • Machine Vision and Industrial Inspection
  • Scientific Photometry
TIFF
Use TIFF when…
  • Professional Print and Desktop Publishing
  • High-Resolution Archival Scanning
  • Master Copies of Digital Photography

More comparisons

PCO-B16 vs ACES → TIFF vs ACES → PCO-B16 vs APNG → TIFF vs APNG → PCO-B16 vs AVCI → TIFF vs AVCI → PCO-B16 vs AVCS → TIFF vs AVCS → PCO-B16 vs AVIF → TIFF vs AVIF → All comparisons →
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