Image MIME Reference
PCO-B16
PCO B16 Image
image/vnd.pco.b16
VS
QuickTime Image Format
image/x-quicktime
QTIF
A complete technical comparison of PCO B16 Image and QuickTime Image Format — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | PCO-B16 | QTIF |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | ✕ No | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | ✕ No | ✕ No |
| EXIF Metadata | ✕ No | ✕ No |
| ICC Color Profile | ✕ No | ✕ No |
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
QuickTime Image Format
image/x-quicktime
Extension
.qtif.qti.qif
Container
QuickTime Atom Container
Compression
Varies (JPEG, SMC, Apple Video, Cinepak, Uncompressed)
Algorithm
QuickTime Image Compression Manager (ICM) Codecs
Color Depth
1-bit to 32-bit (Varies depending on the enclosed codec)
Developed by
Apple Computer, Inc.
Released
1991
Magic Bytes
Varies (Typically begins with a 32-bit size integer followed by 69 64 73 63 ('idsc'))
Browser Support Comparison
| Browser | PCO-B16 | QTIF |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
QTIF
QTIF Strengths
- Extremely flexible architecture allowing it to encapsulate virtually any image compression algorithm available on the host machine
- Supported 32-bit images with alpha channels (transparency) long before PNG became an established standard
Limitations
- Fundamentally tied to Apple's deprecated QuickTime architecture, rendering the files almost entirely unreadable on modern systems without specialized legacy software or FFmpeg
- The 'wrapper' nature of the format means that even if a parser can read the QTIF container, it may fail to render the image if it lacks the specific proprietary codec (like Apple SMC) used to compress the pixel data
- Zero native support in modern web browsers
When to choose which format
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry
QTIF
Use QTIF when…
- Classic Mac OS Applications and Backgrounds
- QuickTime VR Panorama Textures
- 1990s CD-ROM Multimedia Assets