Image MIME Reference
PCO-B16
PCO B16 Image
image/vnd.pco.b16
VS
Adobe Photoshop Document
image/vnd.adobe.photoshop
PSD
A complete technical comparison of PCO B16 Image and Adobe Photoshop Document — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | PCO-B16 | PSD |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | ✕ No | Yes |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | ✕ No | Yes |
| EXIF Metadata | ✕ No | Yes |
| ICC Color Profile | ✕ No | Yes |
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Adobe Photoshop Document
image/vnd.adobe.photoshop
Extension
.psd.psb.pdd
Container
Adobe Photoshop Document (PSD/PSB)
Compression
Uncompressed / RLE (Run-Length Encoding) / ZIP
Algorithm
RLEZIP (with or without prediction)None
Color Depth
1-bit (Bitmap), 8-bit, 16-bit, 32-bit (Float/HDR)
Developed by
Adobe Systems
Released
1990
Magic Bytes
38 42 50 53
Browser Support Comparison
| Browser | PCO-B16 | PSD |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
PSD
PSD Strengths
- The undisputed global standard for layered raster graphics and non-destructive image editing
- Supports incredibly complex compositions combining raster data, vector shapes, live text, and adjustment layers
- Full support for advanced color spaces (CMYK, Lab, multi-channel) and 32-bit floating-point HDR workflows
Limitations
- Proprietary format: while the specification is published, complete feature-parity is rarely achieved by third-party software (e.g., smart objects and complex layer styles often break)
- Files can reach enormous sizes (gigabytes) due to the preservation of unflattened, high-resolution layer data
- Zero support for native rendering in web browsers or standard mobile image viewers
When to choose which format
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry
PSD
Use PSD when…
- Professional Photo Retouching
- Digital Painting and Illustration
- UI/UX Design Workflows
- Graphic Design and Print Production