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Image MIME Reference
JPEG-XS-Sequence

JPEG XS Image Sequence (HEIF Container)

image/jxss
VS

PCO B16 Image

image/vnd.pco.b16
PCO-B16

A complete technical comparison of JPEG XS Image Sequence (HEIF Container) and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature JPEG-XS-Sequence PCO-B16
Transparency (Alpha) Yes ✕ No
Animation Support Yes ✕ No
Progressive Loading ✕ No ✕ No
HDR Support Yes ✕ No
EXIF Metadata Yes ✕ No
ICC Color Profile Yes ✕ No
JPEG XS Image Sequence (HEIF Container)
image/jxss
Extension
.jxss.jxs
Container HEIF / ISOBMFF (ISO/IEC 23008-12)
Compression Lossy (Visually Lossless) / Mathematically Lossless
Algorithm
JPEG XS (ISO/IEC 21122-1)
Color Depth 8-bit, 10-bit, 12-bit, 14-bit, 16-bit
Developed by Joint Photographic Experts Group (JPEG)
Released 2019
Magic Bytes
XX XX XX XX 66 74 79 70 6A 78 73 73
Full JPEG-XS-Sequence reference →
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container PCO B16 Binary Container
Compression Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth 16-bit (Monochrome or Bayer Raw Color)
Developed by PCO AG (Excelitas PCO GmbH)
Released Early 2000s
Magic Bytes
50 43 4F 2D
Full PCO-B16 reference →

Browser Support Comparison

Browser JPEG-XS-Sequence PCO-B16
Chrome Chrome
Firefox Firefox
Safari Safari
Edge Edge
IE IE (Legacy)
JPEG-XS-Sequence

JPEG-XS-Sequence Strengths

  • Provides sub-millisecond encoding and decoding latency across a video sequence while retaining visually lossless quality
  • Leverages the robust ISOBMFF track structures for accurate frame timing, audio synchronization, and metadata handling
  • Optimized for professional video production and IP broadcasting workflows
Limitations
  • Zero web browser compatibility, limiting its use entirely to professional and industrial hardware workflows
  • Compression ratios are significantly lower than consumer video codecs like HEVC or AV1
  • Extremely niche format that requires highly specialized broadcast hardware or custom software libraries to process
PCO-B16

PCO-B16 Strengths

  • Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
  • The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
  • Generates massive file sizes due to the complete lack of image compression [1.3.1]
  • Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
  • Strictly tied to the hardware and software ecosystems of a single camera manufacturer

When to choose which format

JPEG-XS-Sequence
Use JPEG-XS-Sequence when…
  • Live Broadcast Video Snippets
  • Medical Imaging Sequences
  • HDR Burst Photography Archiving
  • Automotive & Drone Video Storage
PCO-B16
Use PCO-B16 when…
  • Microscopy and Life Sciences
  • High-Speed Camera Recording
  • Machine Vision and Industrial Inspection
  • Scientific Photometry
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