Image MIME Reference
JPEG
JPEG Image
image/jpeg
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of JPEG Image and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
JPEG wins on browser support
Feature Support
| Feature | JPEG | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | ✕ No | ✕ No |
| Animation Support | ✕ No | ✕ No |
| Progressive Loading | Yes | ✕ No |
| HDR Support | ✕ No | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
JPEG Image
image/jpeg
Extension
.jpg.jpeg.jpe.jfif
Container
JFIF / Exif
Compression
Lossy
Algorithm
DCT (Discrete Cosine Transform)
Color Depth
8-bit
Developed by
Joint Photographic Experts Group
Released
1992
Magic Bytes
FF D8 FF
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | JPEG | PCO-B16 |
|---|---|---|
Chrome
|
✓ All
|
✕ |
Firefox
|
✓ All
|
✕ |
Safari
|
✓ All
|
✕ |
Edge
|
✓ All
|
✕ |
IE (Legacy)
|
✓
|
✕ |
JPEG
JPEG Strengths
- Universal support — every browser, OS, and application handles JPEG
- Excellent compression for complex photographs with natural color gradients
- Rich metadata support: EXIF (GPS, camera settings), ICC color profiles
Limitations
- No transparency — cannot have a transparent background
- Lossy compression introduces visible artifacts on sharp edges and text
- No animation support
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
JPEG
Use JPEG when…
- Photography
- Websites
- Social Media
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry