Image MIME Reference
HEIF
High Efficiency Image File Format
image/heif
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of High Efficiency Image File Format and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | HEIF | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | Yes | ✕ No |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
High Efficiency Image File Format
image/heif
Extension
.heif.hif
Container
HEIF / ISOBMFF (ISO/IEC 14496-12)
Compression
Lossy / Lossless
Algorithm
Codec Agnostic (HEVC, AVC, JPEG, AV1)
Color Depth
8-bit, 10-bit, 12-bit, 16-bit
Developed by
Moving Picture Experts Group (MPEG)
Released
2015
Magic Bytes
XX XX XX XX 66 74 79 70 6D 69 66 31
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | HEIF | PCO-B16 |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
HEIF
HEIF Strengths
- Highly flexible container that can store image bursts, animations, focal stacks, and stereo 3D images in one file
- Natively supports depth maps and alpha channels, making it perfect for computational photography
- When paired with modern codecs like HEVC or AV1, it provides massive storage savings over legacy formats like JPEG
Limitations
- Codec agnosticism makes broad software decoding difficult, as the container might hold proprietary or unsupported codecs
- Zero cross-platform web browser support, requiring conversion for online publishing
- Often confused with the more specific 'image/heic' and 'image/avif' MIME types
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
HEIF
Use HEIF when…
- Digital Photography
- Camera Capture
- Image Archiving
- Multi-image composites
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry