Image MIME Reference
HEIC
High Efficiency Image Container
image/heic
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of High Efficiency Image Container and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
HEIC wins on browser support
Feature Support
| Feature | HEIC | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | Yes | ✕ No |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
High Efficiency Image Container
image/heic
Extension
.heic
Container
HEIF / ISOBMFF
Compression
Lossy / Lossless
Algorithm
HEVC (H.265)
Color Depth
8-bit, 10-bit, 12-bit, 16-bit
Developed by
MPEG (Standard) / Apple (Adoption)
Released
2017
Magic Bytes
XX XX XX XX 66 74 79 70 68 65 69 63
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | HEIC | PCO-B16 |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✓ 11+
|
✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
HEIC
HEIC Strengths
- Exceptional compression efficiency — stores images at roughly half the file size of JPEG with equal or better visual quality
- Natively supports modern photography features like depth maps, 16-bit color, HDR, and alpha channel transparency
- Can store image bursts, focal stacks, and animations (Live Photos) within a single file
Limitations
- Heavily encumbered by software patents, leading to very poor adoption outside the Apple ecosystem
- Not supported by standard web browsers (except Safari), requiring server-side or client-side conversion for web delivery
- Windows requires downloading a separate (often paid) extension from the Microsoft Store to view natively
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
HEIC
Use HEIC when…
- iOS / iPhone Photography
- macOS Ecosystem
- High-Quality Image Archiving
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry