Image MIME Reference
HEIC-Sequence
HEVC Image Sequence (HEIF Container)
image/heic-sequence
VS
PCO B16 Image
image/vnd.pco.b16
PCO-B16
A complete technical comparison of HEVC Image Sequence (HEIF Container) and PCO B16 Image — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
HEIC-Sequence wins on browser support
Feature Support
| Feature | HEIC-Sequence | PCO-B16 |
|---|---|---|
| Transparency (Alpha) | Yes | ✕ No |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | Yes | ✕ No |
| ICC Color Profile | Yes | ✕ No |
HEVC Image Sequence (HEIF Container)
image/heic-sequence
Extension
.heics.heic
Container
HEIF / ISOBMFF (ISO/IEC 14496-12)
Compression
Lossy / Lossless
Algorithm
HEVC (H.265)
Color Depth
8-bit, 10-bit, 12-bit, 16-bit
Developed by
Moving Picture Experts Group (MPEG) / Apple
Released
2017
Magic Bytes
XX XX XX XX 66 74 79 70 68 65 76 63
PCO B16 Image
image/vnd.pco.b16
Extension
.b16
Container
PCO B16 Binary Container
Compression
Uncompressed (Raw Sensor Data)
Algorithm
None
Color Depth
16-bit (Monochrome or Bayer Raw Color)
Developed by
PCO AG (Excelitas PCO GmbH)
Released
Early 2000s
Magic Bytes
50 43 4F 2D
Browser Support Comparison
| Browser | HEIC-Sequence | PCO-B16 |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✓ 11+
|
✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
HEIC-Sequence
HEIC-Sequence Strengths
- Incredibly efficient storage for bursts and short animations compared to GIF or motion JPEG
- Supports 16-bit color, HDR, and alpha channel transparency across all frames
- Shares frame data blocks, meaning the base image and animation data are heavily optimized for space
Limitations
- Zero support in web browsers outside the Apple ecosystem (Chrome, Firefox, Edge do not support it)
- Heavily encumbered by HEVC patent pools, hindering open-source adoption
- Complex container structure makes parsing and decoding difficult without specialized libraries
PCO-B16
PCO-B16 Strengths
- Preserves exact, uncompressed 16-bit raw sensor data, which is critically important for accurate scientific measurements, fluorescence microscopy, and photometry
- The simple, linear struct header is highly predictable and easy to parse in custom Python, MATLAB, or C++ scripts for researchers building bespoke pipelines
Limitations
- Generates massive file sizes due to the complete lack of image compression [1.3.1]
- Completely unsupported by standard operating systems, web browsers, and consumer image editing suites
- Strictly tied to the hardware and software ecosystems of a single camera manufacturer
When to choose which format
HEIC-Sequence
Use HEIC-Sequence when…
- Apple Live Photos
- Burst Photography
- High-Quality Animations
- Cinemagraphs
PCO-B16
Use PCO-B16 when…
- Microscopy and Life Sciences
- High-Speed Camera Recording
- Machine Vision and Industrial Inspection
- Scientific Photometry