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Image MIME Reference
DICOM-RLE

DICOM Run-Length Encoding

image/dicom-rle
VS

JPEG XR (HD Photo)

image/vnd.ms-photo
JPEG-XR

A complete technical comparison of DICOM Run-Length Encoding and JPEG XR (HD Photo) — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature DICOM-RLE JPEG-XR
Transparency (Alpha) ✕ No Yes
Animation Support Yes ✕ No
Progressive Loading ✕ No Yes
HDR Support Yes Yes
EXIF Metadata ✕ No Yes
ICC Color Profile Yes Yes
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container DICOM (PS3.10)
Compression Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth 8-bit, 16-bit, 24-bit
Developed by National Electrical Manufacturers Association (NEMA) / ACR
Released 1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Full DICOM-RLE reference →
JPEG XR (HD Photo)
image/vnd.ms-photo
Extension
.jxr.wdp.hdp
Container TIFF-like Image File Directory (IFD)
Compression Lossy (Lapped Bi-orthogonal Transform) / Lossless
Algorithm
Lapped Bi-orthogonal Transform (LBT)
Color Depth 8-bit (Grayscale, RGB, CMYK), 16-bit, 32-bit Floating Point (HDR)
Developed by Microsoft Corporation (later Joint Photographic Experts Group)
Released 2006
Magic Bytes
49 49 BC 01
Full JPEG-XR reference →

Browser Support Comparison

Browser DICOM-RLE JPEG-XR
Chrome Chrome
Firefox Firefox
Safari Safari
Edge Edge
IE IE (Legacy)
DICOM-RLE

DICOM-RLE Strengths

  • Guarantees lossless preservation of critical medical data necessary for diagnostics
  • Extremely robust metadata structure containing patient information, modality, and spatial geometry
  • Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
  • RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
  • Zero support in web browsers or standard consumer image viewers
  • Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
JPEG-XR

JPEG-XR Strengths

  • Excellent support for 16-bit and 32-bit floating-point HDR images without massive file size bloat
  • Native support for alpha transparency, which standard JPEG fundamentally lacks
  • Computational complexity for decoding/encoding is relatively low, making it hardware-friendly
Limitations
  • Suffered a complete failure of adoption in the web browser market outside of Microsoft's ecosystem
  • Fully superseded by modern, open formats like WebP, AVIF, and JPEG XL which offer better compression and universal browser support
  • Multiple file extensions (.wdp, .hdp, .jxr) and MIME types cause confusion and parsing fragmentation

When to choose which format

DICOM-RLE
Use DICOM-RLE when…
  • Medical Imaging
  • Ultrasound
  • X-Rays / CT / MRI
  • PACS Archives
JPEG-XR
Use JPEG-XR when…
  • Legacy Windows Desktop Backgrounds
  • XPS (XML Paper Specification) Documents
  • Early High Dynamic Range (HDR) Photography
  • DirectX Textures
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