Image MIME Reference
DICOM-RLE
DICOM Run-Length Encoding
image/dicom-rle
VS
Extended Image File Format
image/vnd.xiff
XIFF
A complete technical comparison of DICOM Run-Length Encoding and Extended Image File Format — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | DICOM-RLE | XIFF |
|---|---|---|
| Transparency (Alpha) | ✕ No | ✕ No |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | ✕ No | ✕ No |
| ICC Color Profile | Yes | ✕ No |
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container
DICOM (PS3.10)
Compression
Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth
8-bit, 16-bit, 24-bit
Developed by
National Electrical Manufacturers Association (NEMA) / ACR
Released
1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Extended Image File Format
image/vnd.xiff
Extension
.xif
Container
TIFF-based Proprietary Container
Compression
CCITT Group 3 / Group 4 / LZW / Uncompressed
Algorithm
CCITT Group 4LZWNone
Color Depth
1-bit (Monochrome), 8-bit (Grayscale), 24-bit (RGB)
Developed by
Keyfile Corporation
Released
1994
Magic Bytes
49 49 2A 00 or 4D 4D 00 2A
Browser Support Comparison
| Browser | DICOM-RLE | XIFF |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
DICOM-RLE
DICOM-RLE Strengths
- Guarantees lossless preservation of critical medical data necessary for diagnostics
- Extremely robust metadata structure containing patient information, modality, and spatial geometry
- Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
- RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
- Zero support in web browsers or standard consumer image viewers
- Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
XIFF
XIFF Strengths
- Pioneered early enterprise document workflow integration by binding administrative routing data directly to the document image file
- Leveraged efficient fax compression standards to keep storage requirements low on 1990s server infrastructure
Limitations
- Completely proprietary and obsolete; Keyfile Corporation's software ecosystem no longer exists
- Causes widespread MIME type identification conflicts due to sharing the exact same binary header signature as standard TIFF files
- Zero support in modern operating systems or web browsers
When to choose which format
DICOM-RLE
Use DICOM-RLE when…
- Medical Imaging
- Ultrasound
- X-Rays / CT / MRI
- PACS Archives
XIFF
Use XIFF when…
- Keyfile Enterprise Document Management
- Legacy Corporate Workflow Archival
- Scanned Multi-page Document Routing