Image MIME Reference
DICOM-RLE
DICOM Run-Length Encoding
image/dicom-rle
VS
Multi-resolution Seamless Image Database
image/x-mrsid-image
MrSID
A complete technical comparison of DICOM Run-Length Encoding and Multi-resolution Seamless Image Database — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | DICOM-RLE | MrSID |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | Yes |
| HDR Support | Yes | ✕ No |
| EXIF Metadata | ✕ No | Yes |
| ICC Color Profile | Yes | Yes |
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container
DICOM (PS3.10)
Compression
Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth
8-bit, 16-bit, 24-bit
Developed by
National Electrical Manufacturers Association (NEMA) / ACR
Released
1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Multi-resolution Seamless Image Database
image/x-mrsid-image
Extension
.sid
Container
Proprietary MrSID Container
Compression
Proprietary Wavelet (Lossy) / Proprietary Wavelet (Lossless)
Algorithm
Discrete Wavelet Transform (DWT)
Color Depth
8-bit (Grayscale), 24-bit (RGB), Multi-spectral (Multiple bands)
Developed by
Los Alamos National Laboratory / LizardTech (Extensis)
Released
1992
Magic Bytes
6D 73 69 64
Browser Support Comparison
| Browser | DICOM-RLE | MrSID |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
DICOM-RLE
DICOM-RLE Strengths
- Guarantees lossless preservation of critical medical data necessary for diagnostics
- Extremely robust metadata structure containing patient information, modality, and spatial geometry
- Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
- RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
- Zero support in web browsers or standard consumer image viewers
- Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
MrSID
MrSID Strengths
- Incredible compression ratios enable multi-gigabyte geographical datasets to be stored on standard hard drives or transmitted easily
- Multi-resolution architecture means panning and zooming across a massive map is completely fluid, as the system decodes only the visible quadrant at the required zoom level
- Supports multi-spectral bands critical for remote sensing and agricultural GIS analysis
Limitations
- Deeply proprietary; creating or decoding MrSID files typically requires expensive commercial software or the proprietary Extensis DSDK
- Open-source geospatial libraries like GDAL require compiling against the proprietary SDK to legally enable MrSID support, causing licensing headaches for Linux server deployments
- Not natively viewable on the web without specialized geospatial map servers (like GeoServer or MapServer) tiling the image into PNGs or JPEGs on the fly
When to choose which format
DICOM-RLE
Use DICOM-RLE when…
- Medical Imaging
- Ultrasound
- X-Rays / CT / MRI
- PACS Archives
MrSID
Use MrSID when…
- Geographic Information Systems (GIS)
- Satellite Imagery Archival
- Aerial Orthophotography Mosaics