Image MIME Reference
DICOM-RLE
DICOM Run-Length Encoding
image/dicom-rle
VS
Khronos Texture 2.0
image/ktx2
KTX2
A complete technical comparison of DICOM Run-Length Encoding and Khronos Texture 2.0 — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | DICOM-RLE | KTX2 |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | Yes |
| EXIF Metadata | ✕ No | ✕ No |
| ICC Color Profile | Yes | ✕ No |
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container
DICOM (PS3.10)
Compression
Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth
8-bit, 16-bit, 24-bit
Developed by
National Electrical Manufacturers Association (NEMA) / ACR
Released
1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Khronos Texture 2.0
image/ktx2
Extension
.ktx2
Container
KTX 2.0
Compression
Basis Universal (ETC1S / UASTC) / Zstandard (zstd) Supercompression / Uncompressed
Algorithm
ETC1SUASTCZstandard (zstd)Raw GPU Formats (ASTC, BCn)
Color Depth
8-bit, 16-bit, 32-bit (Float)
Developed by
Khronos Group
Released
2021
Magic Bytes
AB 4B 54 58 20 32 30 BB 0D 0A 1A 0A
Browser Support Comparison
| Browser | DICOM-RLE | KTX2 |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
DICOM-RLE
DICOM-RLE Strengths
- Guarantees lossless preservation of critical medical data necessary for diagnostics
- Extremely robust metadata structure containing patient information, modality, and spatial geometry
- Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
- RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
- Zero support in web browsers or standard consumer image viewers
- Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
KTX2
KTX2 Strengths
- Universal hardware compatibility: write once, transcode anywhere to the target GPU's preferred format (ASTC, BC7, PVRTC, etc.)
- Drastically reduces transmission size over networks thanks to Basis Universal and Zstandard supercompression
- Seamless integration with the glTF ecosystem for optimized 3D asset delivery
Limitations
- Requires WebAssembly (Wasm) decoders and JavaScript loaders for web viewing, increasing initial application payload slightly
- Encoding textures into high-quality Basis Universal UASTC can be computationally intensive and slow
- Zero support in traditional 2D image viewers or native OS previews
When to choose which format
DICOM-RLE
Use DICOM-RLE when…
- Medical Imaging
- Ultrasound
- X-Rays / CT / MRI
- PACS Archives
KTX2
Use KTX2 when…
- glTF 3D Models (KHR_texture_basisu)
- WebGPU and WebGL Applications
- Game Engines (Unity, Unreal, Godot)
- Augmented and Virtual Reality (AR/VR)