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Image MIME Reference
DICOM-RLE

DICOM Run-Length Encoding

image/dicom-rle
VS

JPEG XS Codestream

image/jxsc
JPEG-XS-Codestream

A complete technical comparison of DICOM Run-Length Encoding and JPEG XS Codestream — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature DICOM-RLE JPEG-XS-Codestream
Transparency (Alpha) ✕ No Yes
Animation Support Yes ✕ No
Progressive Loading ✕ No ✕ No
HDR Support Yes Yes
EXIF Metadata ✕ No ✕ No
ICC Color Profile Yes ✕ No
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container DICOM (PS3.10)
Compression Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth 8-bit, 16-bit, 24-bit
Developed by National Electrical Manufacturers Association (NEMA) / ACR
Released 1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Full DICOM-RLE reference →
JPEG XS Codestream
image/jxsc
Extension
.jxsc.jxs
Container None (Raw Codestream)
Compression Lossy (Visually Lossless) / Mathematically Lossless
Algorithm
JPEG XS (ISO/IEC 21122-1)
Color Depth 8-bit, 10-bit, 12-bit, 14-bit, 16-bit
Developed by Joint Photographic Experts Group (JPEG) / intoPIX
Released 2019
Magic Bytes
FF 10
Full JPEG-XS-Codestream reference →

Browser Support Comparison

Browser DICOM-RLE JPEG-XS-Codestream
Chrome Chrome
Firefox Firefox
Safari Safari
Edge Edge
IE IE (Legacy)
DICOM-RLE

DICOM-RLE Strengths

  • Guarantees lossless preservation of critical medical data necessary for diagnostics
  • Extremely robust metadata structure containing patient information, modality, and spatial geometry
  • Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
  • RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
  • Zero support in web browsers or standard consumer image viewers
  • Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
JPEG-XS-Codestream

JPEG-XS-Codestream Strengths

  • Eliminates container overhead, maximizing parsing speed and minimizing latency to fractions of a millisecond
  • Highly optimized for direct hardware implementation in FPGAs and ASICs
  • Perfect for continuous data streaming over IP networks without needing to establish file headers
Limitations
  • Lacks standard container metadata (EXIF, XMP, ICC profiles), meaning color space and orientation data must be handled externally or out-of-band
  • Zero support in web browsers or standard consumer operating systems
  • Often requires specialized broadcast hardware or custom software libraries to decode

When to choose which format

DICOM-RLE
Use DICOM-RLE when…
  • Medical Imaging
  • Ultrasound
  • X-Rays / CT / MRI
  • PACS Archives
JPEG-XS-Codestream
Use JPEG-XS-Codestream when…
  • Hardware Decoding Pipelines (FPGA/ASIC)
  • Live Broadcast Infrastructure
  • Video over IP Transport
  • Embedded Camera Systems
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