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Image MIME Reference
DICOM-RLE

DICOM Run-Length Encoding

image/dicom-rle
VS

High Efficiency Image File Format

image/heif
HEIF

A complete technical comparison of DICOM Run-Length Encoding and High Efficiency Image File Format — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.

Equal browser support

Feature Support

Feature DICOM-RLE HEIF
Transparency (Alpha) ✕ No Yes
Animation Support Yes Yes
Progressive Loading ✕ No ✕ No
HDR Support Yes Yes
EXIF Metadata ✕ No Yes
ICC Color Profile Yes Yes
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container DICOM (PS3.10)
Compression Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth 8-bit, 16-bit, 24-bit
Developed by National Electrical Manufacturers Association (NEMA) / ACR
Released 1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Full DICOM-RLE reference →
High Efficiency Image File Format
image/heif
Extension
.heif.hif
Container HEIF / ISOBMFF (ISO/IEC 14496-12)
Compression Lossy / Lossless
Algorithm
Codec Agnostic (HEVC, AVC, JPEG, AV1)
Color Depth 8-bit, 10-bit, 12-bit, 16-bit
Developed by Moving Picture Experts Group (MPEG)
Released 2015
Magic Bytes
XX XX XX XX 66 74 79 70 6D 69 66 31
Full HEIF reference →

Browser Support Comparison

Browser DICOM-RLE HEIF
Chrome Chrome
Firefox Firefox
Safari Safari
Edge Edge
IE IE (Legacy)
DICOM-RLE

DICOM-RLE Strengths

  • Guarantees lossless preservation of critical medical data necessary for diagnostics
  • Extremely robust metadata structure containing patient information, modality, and spatial geometry
  • Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
  • RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
  • Zero support in web browsers or standard consumer image viewers
  • Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
HEIF

HEIF Strengths

  • Highly flexible container that can store image bursts, animations, focal stacks, and stereo 3D images in one file
  • Natively supports depth maps and alpha channels, making it perfect for computational photography
  • When paired with modern codecs like HEVC or AV1, it provides massive storage savings over legacy formats like JPEG
Limitations
  • Codec agnosticism makes broad software decoding difficult, as the container might hold proprietary or unsupported codecs
  • Zero cross-platform web browser support, requiring conversion for online publishing
  • Often confused with the more specific 'image/heic' and 'image/avif' MIME types

When to choose which format

DICOM-RLE
Use DICOM-RLE when…
  • Medical Imaging
  • Ultrasound
  • X-Rays / CT / MRI
  • PACS Archives
HEIF
Use HEIF when…
  • Digital Photography
  • Camera Capture
  • Image Archiving
  • Multi-image composites
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