Image MIME Reference
DICOM-RLE
DICOM Run-Length Encoding
image/dicom-rle
VS
Digital Picture Exchange
image/dpx
DPX
A complete technical comparison of DICOM Run-Length Encoding and Digital Picture Exchange — covering compression, feature support, browser compatibility, magic bytes, and when to choose each format.
Equal browser support
Feature Support
| Feature | DICOM-RLE | DPX |
|---|---|---|
| Transparency (Alpha) | ✕ No | Yes |
| Animation Support | Yes | ✕ No |
| Progressive Loading | ✕ No | ✕ No |
| HDR Support | Yes | Yes |
| EXIF Metadata | ✕ No | ✕ No |
| ICC Color Profile | Yes | ✕ No |
DICOM Run-Length Encoding
image/dicom-rle
Extension
.dcm.dicom
Container
DICOM (PS3.10)
Compression
Lossless (RLE)
Algorithm
Run-Length Encoding (RLE)
Color Depth
8-bit, 16-bit, 24-bit
Developed by
National Electrical Manufacturers Association (NEMA) / ACR
Released
1993
Magic Bytes
44 49 43 4D (at byte offset 128)
Digital Picture Exchange
image/dpx
Extension
.dpx
Container
DPX (SMPTE ST 268)
Compression
Uncompressed / RLE (Rarely used)
Algorithm
Uncompressed
Color Depth
8-bit, 10-bit, 12-bit, 16-bit, 32-bit (Float)
Developed by
SMPTE (Society of Motion Picture and Television Engineers)
Released
1994
Magic Bytes
53 44 50 58 (Big-endian) / 58 50 44 53 (Little-endian)
Browser Support Comparison
| Browser | DICOM-RLE | DPX |
|---|---|---|
Chrome
|
✕ | ✕ |
Firefox
|
✕ | ✕ |
Safari
|
✕ | ✕ |
Edge
|
✕ | ✕ |
IE (Legacy)
|
✕ | ✕ |
DICOM-RLE
DICOM-RLE Strengths
- Guarantees lossless preservation of critical medical data necessary for diagnostics
- Extremely robust metadata structure containing patient information, modality, and spatial geometry
- Faster to encode and decode than complex compression schemes like JPEG 2000
Limitations
- RLE compression offers very low compression ratios compared to modern codecs like JPEG-LS or JPEG 2000
- Zero support in web browsers or standard consumer image viewers
- Strict data privacy regulations (HIPAA/GDPR) make handling DICOM files complex due to embedded PHI
DPX
DPX Strengths
- Industry standard for transferring uncompressed, high-fidelity film and VFX data
- Rich industry-specific metadata including timecode, keykode, and film stock information
- Supports logarithmic color spaces (LogC, Cineon) to preserve the massive dynamic range of film negatives
Limitations
- Massive file sizes (e.g., a single 4K 10-bit frame is ~50MB, resulting in ~1.2GB per second at 24fps)
- Zero native support in web browsers or consumer OS image viewers
- Requires heavy-duty, fast storage infrastructure (RAID/NVMe) to playback in real-time
When to choose which format
DICOM-RLE
Use DICOM-RLE when…
- Medical Imaging
- Ultrasound
- X-Rays / CT / MRI
- PACS Archives
DPX
Use DPX when…
- Film Scanning
- Visual Effects (VFX)
- Digital Intermediate (DI)
- Color Grading
- Archival